منابع مشابه
Microtubules and motors
New tools and approaches are providing exciting new insights into the structure and function of motors and microtubules and their contributions to cell migration, mitosis, and neuronal function. Janel Titus, from the Wadsworth laboratory (University of Massachusetts, Amherst), discussed the regulation of the plus end– directed mitotic motor Eg5 by the spindle assembly factor, TPX2. Spindle form...
متن کاملTheory of self-assembly of microtubules and motors.
We derive a model describing spatiotemporal organization of an array of microtubules interacting via molecular motors. Starting from a stochastic model of inelastic polar rods with a generic anisotropic interaction kernel, we obtain a set of equations for the local rods concentration and orientation. At large enough mean density of rods and concentration of motors, the model describes an orient...
متن کاملMicrotubules, Motors, and mRNA Localization Mechanisms Watching Fluorescent Messages Move
Proper spatial and temporal localization of specific mRNAs is pivotal in the early stages of development. To dissect the mechanisms of localization, several groups are employing advanced fluorescence microscopy to track RNA movements in live oocytes and embryos.
متن کاملPhysical properties determining self-organization of motors and microtubules.
In eukaryotic cells, microtubules and their associated motor proteins can be organized into various large-scale patterns. Using a simplified experimental system combined with computer simulations, we examined how the concentrations and kinetic parameters of the motors contribute to their collective behavior. We observed self-organization of generic steady-state structures such as asters, vortic...
متن کاملPlus-end motors override minus-end motors during transport of squid axon vesicles on microtubules
Plus- and minus-end vesicle populations from squid axoplasm were isolated from each other by selective extraction of the minus-end vesicle motor followed by 5'-adenylyl imidodiphosphate (AMP-PNP)-induced microtubule affinity purification of the plus-end vesicles. In the presence of cytosol containing both plus- and minus-end motors, the isolated populations moved strictly in opposite directions...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2012
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e11-12-0975